产品货号：
Z16180
中文名称：
FOXP1抗体
英文名称：
Anti-FOXP1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-FOXP1 Antibody |
| 指标别名 | 12CC4;forkhead box P1;Forkhead box protein P1;FOXP1;hFKH1B;HSPC215;QRF1 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC |
| 基因名称 | FOXP1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the C-terminus of human FOXP1(657-677aa HSPDFDHDRDYEDEPVNEDME),identical to the related rat and mouse sequences. |
| 实际分子量 | 78KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | FOXP1("forkhead box P1") is a gene that is necessary for the proper development of the brain and lung in mammals.It is a member of the large FOX family of transcription factors.This gene belongs to subfamily P of the forkhead box(FOX) transcription factor family.Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood.Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains.This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region(3p14.1) reported to contain a tumor suppressor gene(s).Alternative splicing results in multiple transcript variants encoding different isoforms.It was shown that the embryonic stem cell(ESC)-specific isoform of FOXP1 stimulates the expression of transcription factor genes required for pluripotency,including OCT4,NANOG,NR5A2,and GDF3,while concomitantly repressing genes required for ESC differentiation.This isoform also promotes the maintenance of ESC pluripotency and contributes to efficient reprogramming of somatic cells into induced pluripotent stem cells.These results reveal a pivotal role for an Alternative splicing event in the regulation of pluripotency through the control of critical ESC-specific transcriptional programs(2). |
| Uniprot ID | Q9H334 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | forkhead box P1 |
| 蛋白名全称 | Forkhead box protein P1 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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